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Under the Microscope

Tuesday, October 11, 2016   (0 Comments)
Posted by: Kristen Pappaterra
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Bioscience is an industry that generates billions each year with surprisingly little visibility. But that could soon change.

Jobs of the Future: Michael Cassidy, president and CEO of the Georgia Research Alliance at Georgia State University’s Institute for Biomedical Sciences

Jobs of the Future: Michael Cassidy, president and CEO of the Georgia Research Alliance at Georgia State University’s Institute for Biomedical Sciences

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There’s a multibillion-dollar industry growing in Georgia, but it’s been just under the radar so far. Bioscience – a massive sector encompassing pharmaceuticals, medical devices and equipment, diagnostics, biologics and the burgeoning area of digital health IT – generates more than $15 billion in sales for Georgia each year, yet it remains a hidden industry to those outside it.

“People who aren’t in the industry itself are not quite aware of the vibrant community that we have in Georgia,” says Jordan Rose, executive director of the Georgia BioEd Institute, which works to develop Georgia’s workforce, education and leadership in the life sciences. “Most people think about Cambridge, Massachusetts, or San Francisco and San Diego as the hotbeds of biotechnology, but Georgia is a leader in the industry. We have a lot of amazing companies and innovations coming out of this area.”

Thankfully, some are starting to take notice. In its 2015 World’s Most Competitive Cities report, Site Selection magazine named Metro Atlanta the fifth-strongest North American city for life sciences, citing its low cost of living and valuable research centers – and shifting the spotlight a little closer in the process.


Industry Impact

“The biomedical industry is an industry that every state is after,” says Michael Cassidy, president and CEO of the Georgia Research Alliance, an integral player in securing and supporting funding for the state’s research institutions. “The industry is making contributions to our quality of life in very noticeable and measurable ways, and every state wants to be a part of that.”

Over the past 25 years, the GRA has played a key role in the development of numerous biotech breakthroughs, including one of the most prescribed HIV treatment medications in the world. Emtriva, developed at Emory University in the early 1990s, is now taken by nine out of 10 people treated for HIV in the United States. Gilead Sciences and Royalty Pharma purchased Emtriva’s royalty interest in 2005 for $525 million, which has been reinvested at Emory to further research and development in bioscience.

Georgia’s universities – and the startups they spin off – have also developed technologies for painless vaccines, earlier detection of autism and Alzheimer’s, and even real-time monitoring of cardiovascular health. CardioMEMS, an implantable device the size of a small paper clip, can transmit real-time data on blood pressure, heart rate and cardiac output from inside a patient’s pulmonary artery. The company was acquired by St. Jude Medical in 2014 for more than $450 million, and a 2011 clinical trial reported a 37 percent reduction in heart failure hospitalizations for patients with the device – proving that the impacts of Georgia’s bioscience industry transcend dollars and cents, as well as state lines.

Inside the state, though, the impact reaches the billions. A joint study between the University of Georgia and Georgia Bio, the trade organization for Georgia’s bioscience industry, puts the economic impact of bioscience in the state at $16.7 billion in sales and $6.9 billion in state gross domestic product, with another $1 billion in state GDP from life sciences research at the state’s colleges and universities.

Moreover, a 2016 TEConomy Partners/BIO report cites the annual average salary for the bioscience industry in Georgia is just shy of $77,000, with almost 30,000 jobs at 2,047 bioscience organizations. Compared to the average private-sector annual salary of just under $49,000, jobs in the bioscience industry are high paying – and extremely lucrative for the state.

“What’s exciting here in Georgia,” says Cassidy, “is that it’s very clear with what the state has been doing to provide some of the economic development investment, whether it’s from the Department of Economic Development or GRA, that this is a direction in which we want to take the state because we know that these are the jobs of the future.”

Why are these startups and researchers choosing Georgia? It’s a mix of factors, say industry leaders, including Georgia’s low cost of living, pro-growth business environment and strong infrastructure, including easy access to rail and international air travel. Another key factor is the state’s research institutions and research centers, which bolster the industry by boosting its scientific reputation and helping to attract the nation’s best researchers.


Nationally Recognized Research Centers

There are dozens of university research institutions across Georgia, stretching from the University of Georgia’s Complex Carbohydrate Research Center in Athens to the Center for Biotechnology and Genomic Medicine and the Immunotherapy Center, both at Augusta University. The majority, however, are clustered in Metro Atlanta around Georgia Tech, Emory, Morehouse School of Medicine, Georgia State University and Clark Atlanta University. Plus, many are collaborations between and among two or more of these institutions.

One such collaboration, the Center for Behavioral Neuroscience, is a consortium of seven institutions: Emory, Georgia Tech, Morehouse College, Morehouse School of Medicine, Spelman College, Clark Atlanta and lead institution Georgia State University.

The center was founded in 1999 as a National Science Foundation Science and Technology Center, and its more than 150 neuroscientists’ research includes the roles of oxytocin and vasopressin in social behavior, with the goal of applying discoveries to better understand, detect and treat psychiatric disorders like post-traumatic stress disorder, autism and depression, says its director, Elliott Albers.

Current grant-funded research is also investigating the neurobiology behind positive emotions and social behaviors like cooperation, compassion and empathy, as well as the evolution of language and speech in primates.

Georgia Tech announced in January a new research center devoted to standardizing the production and testing of living cells. The Marcus Center for Therapeutic Cell Characterization and Manufacturing (MC3M) – the first of its kind in the country – represents a $23-million investment from the Marcus Foundation, Georgia Tech and the GRA. Research conducted in the center’s facilities could lead to more reliable, cost-effective procedures for producing large amounts of high-quality stem cells and immune cells, which can be used in cell-based treatments for diseases like cancer, spinal cord injury, autoimmune disorders and neurodegenerative diseases.

And at the Global Center for Medical Innovation (GCMI) in Midtown, startups and researchers can find the valuable resources they need to get their ideas from prototype to market – a feat that might not happen otherwise.

“Historically, innovation and commercialization are separate activities and not always well-linked together. GCMI is really helping bridge that gap and providing a place for medical device innovators to help move their technologies and products and startups forward,” says Tiffany Wilson, the center’s executive director. “The premise was that if we had a physical space that had the product development, engineering expertise, machine tools and clean room space, we could bring together an ecosystem around that to really help guide that transition from the lab to the market.”

Since the GCMI’s opening in April 2012, Wilson’s team has helped more than 60 medical device product teams navigate through product development and regulatory approvals to commercialization, including Atlanta-based NFANT Lab. Born out of the University of Kentucky, NFANT Lab’s research team developed a real-time infant feeding monitoring system that collects and transmits data to improve feeding methods for babies in neonatal intensive care units.

“What GCMI did for us was give us access to engineers, equipment and space that we would have had to do on our own. I think we could have done it, but it probably would have taken longer and it would have been more expensive,” says Lou Malice, NFANT Lab’s CEO. “That’s where the real value is. When you’re early stage and don’t have a lot of money and you need to really protect your capital, those types of incubator spaces are extremely important to get those companies off the ground.”

What do these research centers – and the dozens of others across Georgia – mean to the state? For one, says MC3M Director Krishnendu Roy, they give the state the tools to attract top researchers from across the country to continue to produce groundbreaking research.

“These centers certainly elevate the state’s reputation significantly. Georgia’s flagship research universities are already well recognized, but focused, multidisciplinary centers of excellence that are nationally reputed and recognized to be leaders add hugely to the state’s reputation and help attract new talent.”

Cassidy agrees: “All of the people that we have been involved with in recruiting to the state, they’re all coming here because they see the environment, they see the ecosystem and they see the desire of the state to put the tools and resources in place to do these kinds of things.

“They’re coming here because they see this as a place where the ecosystem and tools are available …. And many of the scholars that we’ve attracted are so well known in their particular field that they really serve as a magnet to attract others in that field.”


Collaborating for Success

Metro Atlanta’s valuable assets – nationally recognized research institutions and centers, strong research talent, startup incubators, and easy access to rail and international flights – are big factors in Georgia’s emergence as a national bioscience hub, but they also make another key aspect to success – collaboration – that much easier.

“In Midtown Atlanta, in basically four square miles you’ve got all the assets and infrastructure to go from a medical device technology concept through clinical trials without really leaving Atlanta,” says Wilson. “I don’t see people anywhere else in the country really working in that way, in that collaborative fashion.”

Collaboration – both between the state’s research institutions and among the players in its supporting ecosystem – is vital to achieving research goals. It’s also been a motivating factor for the formation of some of the state’s largest bioscience support organizations.

“Collaboration is one of the reasons that our organization was founded, really as a platform to bring universities together to look at opportunities,” says Cassidy. “One of the reasons we see collaboration so strong in biomedical science is because all of the easy problems have been solved. The really big problems require multidisciplinary teams to work on them.”

At the Center for Behavioral Neuroscience, Albers’ team is working with Mark Wilson, a researcher at Emory University’s Yerkes National Primate Research Center, to study the basic mechanisms involved in social stress under a National Institute of Mental Health grant. This collaboration allows the teams to do parallel studies in hamsters at the center and rhesus monkeys at Yerkes to see if the same mechanisms are at play in the two species. “That adds a whole new dimension to the investigation and brings us a lot closer to clinical impact of these studies,” says Albers.

Outside of the lab, collaboration is necessary to take an idea from concept to prototype, and then from prototype to viable commercial product. This need for continued support has sprouted a handful of university incubators and tech transfer centers, as well as supporting centers like GCMI. It’s also led to increased funding sources, like the Bio/Med Investor Network. Launched in 2015, the network provides angel funding for bioscience, medical technologies and digital health companies. In its first year, the network invested more than $1.5 million in five companies, says Georgia Bio President and CEO Russell Allen.

Though Georgia’s bioscience industry has grown substantially in recent years, there’s still a lot of work to be done. Industry leaders point to the need for more bioscience management talent to take startups from early commercialization to sustained development. There’s also the funding gap between product development and commercialization – “jumping the chasm,” as Malice puts it. Many companies make it through development with a viable product, but bringing it to market successfully is still a daunting challenge for many, from both a funding and leadership perspective.

Tackling these problems will require a sustained, focused and collaborative effort from all of the industry’s key players. “I see it as a never-ending exercise,” says GCMI’s Wilson.

“How can we create an ecosystem and a process for making it easier for innovators? If we can make it easier and more predictable,” she says, “we can see more investment in the Southeast in the medtech industry, more startups, more jobs and more overall economic growth.”


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